LDC1267

Product Name: LDC1267
CAS No.: 1361030-48-9
Chemical Name: LDC1267
Synonyms: CS-1641;LDC1267;LDC 1267;LDC-1267;LDC1267 USP/EP/BP;LDC 1267,LDC1267,Tyro3,Inhibitor,LDC-1267,inhibit,TAM Receptor,Axl,Mer;N-[4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluoro-phenyl]-4-ethoxy-1-(4-fluoro-2-methyl-phenyl)pyrazole-3-carboxamide;N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluoro-2-methylphenyl)-1H-pyrazole-3-carboxamide;N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluoro-2-methylphenyl)-1H-pyrazole-3-carboxamide;1H-Pyrazole-3-carboxamide, N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluoro-2-methylphenyl)-
CBNumber: CB02734808
Molecular Formula: C30H26F2N4O5
Formula Weight: 560.55
MOL File: 1361030-48-9.mol

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LDC1267 Property

Boiling point:: 628.4±55.0 °C(Predicted)
Density: 1.32±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in H2O; insoluble in EtOH; ≥20.75 mg/mL in DMSO
form: solid
pka: 9.36±0.70(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29459
Product name: LDC-1267
Packaging: 1mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 29459
Product name: LDC-1267
Packaging: 25mg
Price: $553
Updated: 2024/03/01

Cayman Chemical

Product number: 29459
Product name: LDC-1267
Packaging: 5mg
Price: $145
Updated: 2024/03/01

Cayman Chemical

Product number: 29459
Product name: LDC-1267
Packaging: 10mg
Price: $239
Updated: 2024/03/01

AK Scientific

Product number: 1703DN
Product name: CID56847486
Packaging: 5mg
Price: $260
Updated: 2021/12/16

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LDC1267 Chemical Properties,Usage,Production

Biological Activity

LDC1267 is a highly selective TAM kinase inhibitor with IC50s of <5 nM, 8 nM, and 29 nM for Mer, Tyro3, and Axl, respectively. Low activity against Met, Aurora B, Lck, Src, and CDK8.

in vitro

LDC1267 moderately affected proliferation in 11 of 95 different cell lines with IC50 >5 μM. In NKG2D-activated NK cells, it abrogates the inhibitory effect of Gas6 stimulation.

in vivo

In B16F10 melanoma-bearing mice, LDC1267 (20 mg/kg, ip) potently enhanced anti-metastatic NK cell activity and resisted tumor metabolism without severe cytotoxicity.

target

Target	Value
Mer (Cell-free assay)	<5 nM
Tyro3 (Cell-free assay)	8 nM
Axl (Cell-free assay)	29 nM

LDC1267 Preparation Products And Raw materials

Raw materials

Preparation Products

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LDC1267 Suppliers

China 68 India 1 United States 11 Global 80

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2784
Advantage: 58

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9926
Advantage: 65

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4662
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 19892
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6393
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19553
Advantage: 58

Aladdin Scientific

Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57511
Advantage: 58

1361030-48-9, LDC1267Related Search:

Tofacitinib citrate Lapatinib UNC2250 CAL-101 Ganetespib Olaparib

LDC1267

N-[4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluoro-phenyl]-4-ethoxy-1-(4-fluoro-2-methyl-phenyl)pyrazole-3-carboxamide

N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluoro-2-methylphenyl)-1H-pyrazole-3-carboxamide

CS-1641

LDC 1267;LDC-1267

1H-Pyrazole-3-carboxamide, N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluoro-2-methylphenyl)-

LDC1267 USP/EP/BP

N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluoro-2-methylphenyl)-1H-pyrazole-3-carboxamide

LDC 1267,LDC1267,Tyro3,Inhibitor,LDC-1267,inhibit,TAM Receptor,Axl,Mer

1361030-48-9

136030-48-9

C30H26F2N4O5

Inhibitors